The CDHR3 gene was identified and associated with asthma hospitalization.
CDHR3 produces a protein called “cadherin,” usually found in the cells lining the airways and lungs, as well as in the cells of the immune system.
Mutated CDHR3 cadherin has an abnormally high number of molecules “on the surface” of the cells exposing the protein to viruses and allergens that could bind to the protein and trigger an abnormal airway response that could lead to asthma and allergies.
Asthma/Allergy and the CDHR3 Gene
The goal of this project is to characterize a variant protein (cadherin) and ultimately find a molecule that will neutralize it and alleviate the detrimental consequences of the mutation.